Asymmetric Syntheses of β-Amino Acids by the Addition of Chiral Amines to C=C Double Bonds

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概要

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• Asymmetric syntheses of β-amino acids were achieved by the addition of chiral amines, R (+)- and S (-)-α-methylbenzylamines (1b and 1c), to crotonitrile, methyl crotonate (5a), l-menthyl crotonate (5b), ethyl cinnamate (5c), and methacrylonitrile, and by the addition of benzylamine (1a) to 5b, in the range of 2-19% optical purities. Among them, the configuration of the resulting β-amino acids was same as 1b and 1c used, in the reactions with crotonitrile and 5c, but was different in the cases of 5a and 5b and methacrylonitrile.

• 公益社団法人日本薬学会の論文
• 1977-06-25

著者

• 古川 潮

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 大川原 正

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 寺脇 由里子

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 大川原 正

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 寺脇 由里子

  Faculty Of Pharmaceutical Sciences Kumamoto University

関連論文

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