Studies on Antitumor Substances. XIV. Syntheses of Bisquarternary Ammonium Salts and the Reaction with Nucleophiles

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概要

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• Several bisquarternary ammonium salts were synthesized and tested as to their antitumor activity. However, none of them exhibited any effective activity. Additionally, alkylation of nucleophiles with quarternary ammonium salts, dimethylaminomethyl p-tolyl ether methiodide and ethylene bis (N, N-diethyl-N-methylammonium iodide), was examined. Dimethylaminomethyl p-tolyl ether methiodide reacted successfully with nucleophiles, such as amine, thiol and alcohol, to give the expected compounds in which p-tolyloxymethyl group was introduced to the nucleophilic compounds. On the other hand, ethylene bis (N, N-diethyl-N-methylammonium iodide) reacted with thiophenol and diethyl malonate to give the methylated compounds, methyl phenyl sulfide and diethyl malonate respectively.

• 社団法人日本薬学会の論文
• 1972-01-25

著者

• 古川 潮

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 石井 信親

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 藤野 洋子

  Institute for Medical and Dental Engineering, Tokyo Medical and Dental University

• 林清 五郎

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 藤野 洋子

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 上城 洋一

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 藤野 洋子

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• 林清 五郎

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 上城 洋一

  Faculty Of Pharmaceutical Sciences Kumamoto University

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