Asymmetric Syntheses of β-Amino Acid and Aspartic Acid by Reformatsky Reaction
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概要
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Asymmetric syntheses of β-amino acids and aspartic acid were achieved by the reaction of optically active Schiff bases prepared from aldehydes and optically active amines, R (+)- and S (-)-α-methylbenzylamines, with Reformatsky reagents in the range of 18-28% optical purities. When the Schiff bases having R (+)-amino component were used in the reaction, (S)-β-amino acids and (R)-aspartic acid were formed. The use of the Schiff bases involving S (-)-amino component gave (R)-β-amino acids and (S)-aspartic acid. The reaction of Schiff bases prepared from aldehydes and benzylamine with optically active Reformatsky reagents having l-menthyl ester gave (S)-β-amino acids and (R)-aspartic acid in the range of 2-5% optical purities. The steric course were also presumed.
- 公益社団法人日本薬学会の論文
- 1978-01-25
著者
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古川 潮
Faculty Of Pharmaceutical Sciences Kumamoto University
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大川原 正
Faculty of Pharmaceutical Sciences, Kumamoto University
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野口 芳秀
Faculty of Pharmaceutical Sciences, Kumamoto University
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寺脇 由里子
Faculty of Pharmaceutical Sciences, Kumamoto University
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野口 芳秀
Faculty Of Pharmaceutical Sciences Kumamoto University
-
大川原 正
Faculty Of Pharmaceutical Sciences Kumamoto University
-
寺脇 由里子
Faculty Of Pharmaceutical Sciences Kumamoto University
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