Asymmetric Synthesis of β-Amino-α, α-dimethyl-β-phenylpropionic Acid. The Reactions of Chiral Schiff Bases with Dimethylketene and with Reformatsky Reagent
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概要
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Asymmetric synthesis of optically active β-amino-α, α-dimethyl-β-phenylpropionic acid (7) was achieved by the reaction of chiral Schiff bases with dimethylketene or with Reformatsky reagent, in the range of 33-35% optical purities. The specific rotation and configuration of 7 were determined by correlation with authentic R (+)-β-benzoylamino-α, α-dimethyl-β-phenylethanol. The steric courses of these reactions are discussed.
- 公益社団法人日本薬学会の論文
- 1979-11-25
著者
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古川 潮
Faculty Of Pharmaceutical Sciences Kumamoto University
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大川原 正
Faculty of Pharmaceutical Sciences, Kumamoto University
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野口 芳秀
Faculty of Pharmaceutical Sciences, Kumamoto University
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寺脇 由里子
Faculty of Pharmaceutical Sciences, Kumamoto University
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野口 芳秀
Faculty Of Pharmaceutical Sciences Kumamoto University
-
大川原 正
Faculty Of Pharmaceutical Sciences Kumamoto University
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寺脇 由里子
Faculty Of Pharmaceutical Sciences Kumamoto University
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