Asymmetric Synthesis of β-Amino-α, α-dimethyl-β-phenylpropionic Acid. The Reactions of Chiral Schiff Bases with Dimethylketene and with Reformatsky Reagent

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概要

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• Asymmetric synthesis of optically active β-amino-α, α-dimethyl-β-phenylpropionic acid (7) was achieved by the reaction of chiral Schiff bases with dimethylketene or with Reformatsky reagent, in the range of 33-35% optical purities. The specific rotation and configuration of 7 were determined by correlation with authentic R (+)-β-benzoylamino-α, α-dimethyl-β-phenylethanol. The steric courses of these reactions are discussed.

• 公益社団法人日本薬学会の論文
• 1979-11-25

著者

• 古川 潮

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 大川原 正

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 野口 芳秀

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 寺脇 由里子

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 野口 芳秀

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 大川原 正

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 寺脇 由里子

  Faculty Of Pharmaceutical Sciences Kumamoto University

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