Studies on Application of Amino Acid as Medicinal Agent. I. Syntheses of Amino-tert-alcohol Derivatives

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概要

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• In order to find non-narcotic analgesics, 54 compounds of amino-tert-alcohol, in which a variety of substituent groups were involved at the carbon atom in 1-position and at the amino group, were synthesized by reacting various α-and β-amino acid esters with Grignard reagents. These amino acid esters were readily reacted with alkyl Grignard reagents to give the expected compounds. However, when bulky aromatic Grignard reagents were submitted to react, the reactions were found to stop at the stage of intermediate formation of the corresponding ketones.

• 公益社団法人日本薬学会の論文
• 1969-01-25

著者

• 古川 潮

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 林 清五郎

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 藤野 洋子

  Institute for Medical and Dental Engineering, Tokyo Medical and Dental University

• 藤野 洋子

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 藤野 洋子

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• 大川原 正

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 大川原 正

  Tanabe Seiyaku Co., Ltd.

• 松石 直人

  Tokyo Tanabe Seiyaku Co., Ltd.

• 林清 五郎

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 松石 直人

  Tokyo Tanabe Seiyaku Co. Ltd.

関連論文

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