Reaction of Biguanides and Related Compounds. VI. Condensation of N-Amidino-O-alkylisourea with β-Diketone

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概要

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• N-Amidino-O-alkylisourea was allowed to react with acetylacetone and benzoylacetone. Heating of N-amidino-O-alkylisourea with acetylacetone in boiling ethanol gave 2-alkoxy-4-amino-6-methyl-sym-triazine. On the other hand, the same reaction at room temperature gave 2-alkoxyamidino-4,6-dimethylpyrimidine. The reaction of N-amidino-O-alkylisourea with benzoylacetone in boiling ethanol afforded 2-amino-6-methyl-4-phenylpyrimidine. Difference of the reactivity in these reactions was also discussed.

• 公益社団法人日本薬学会の論文
• 1973-03-25

著者

• 古川 潮

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 林 清五郎

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 林清 五郎

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 小島 洋子

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 吉田 孝利

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 林清 五郎

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 吉田 孝利

  Research Institute, Daiichi Seiyaku Co., Ltd.

• 吉田 孝利

  Research Institute Daiichi Seiyaku Co. Ltd.

関連論文

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