Behaviors of N-(Substituted thio) phthalimides, N-(Substituted thio)-succinimides, and N-(Substituted thio) isatins toward Some Nucleophiles
スポンサーリンク
概要
- 論文の詳細を見る
New compounds of N-(substituted thio) isatins (III) were synthesized and reactions with several nucleophiles were examined in comparison with the reaction using N-(substituted thio) phthalimides (I) and N-(substituted thio) succinimides (II) : All of I, II, and III reacted with organometallic compounds, cyanide ion, and trichloromethyl carbanion to give sulfides (IV), thiocyanates (V), and trichloromethyl sulfides (VI) respectively. Different from I and II, however, the reaction of III with amines afforded 3-amino-1-substituted thio-3-hydroxy-2-oxo-indoles (X), with no formation of any sulfenamides anticipated.
- 公益社団法人日本薬学会の論文
- 1976-08-25
著者
-
古川 潮
Faculty Of Pharmaceutical Sciences Kumamoto University
-
林 清五郎
Faculty Of Pharmaceutical Sciences Kumamoto University
-
須田 千秋
Faculty of Pharmaceutical Sciences, Kumamoto University
-
林清 五郎
Faculty Of Pharmaceutical Sciences Kumamoto University
-
須田 千秋
Faculty Of Pharmaceutical Sciences Kumamoto University
関連論文
- Studies on Antitumor Substances. XIV. Syntheses of Bisquarternary Ammonium Salts and the Reaction with Nucleophiles
- Studies on Antitumor Substances. VII. Reaction of N-Amidino-O-alkylisourea with Some Carboxylic Esters
- The Mechanism for the Reaction of Biguanides with Diethyl Oxalate
- Syntheses of New Pyrazoline Derivatives
- Studies on Antitumor Substances. VI. Chemical Behaviors of Thiosulfonates, Disulfonyl Sulfides, and Related Compounds.
- Studies on Antitumor Substances. V. Reaction of Thiosulfonates with Active Methylene Compounds.
- Studies on the Relationship between the Antitumor and the Antibacterial Activities of Quinone Derivatives.
- Facile Reduction of Intermediates from Carboxylic Acids and 6-Nitro-1-(2-nitrophenylsulfonyloxy)benzotriazole with Sodium Borohydride to Alcohols
- The Reaction of 1,3-Disubstituted Thioureas with α, ω-Dibromoacyl Chlorides and the Formation of Spiro Compounds
- Reactions of p-Toluenesulfinic Acid with Dialkoxy or Diamino Sulfides and Disulfides
- A Facile Preparation of 4-Thiazolone Derivatives from Thioamides and Various Haloacyl Halides in a Biphase System
- Facile Preparations of 1,4-(Diphenylmethyleneamino) piperazine-2,5-diones and N-Phenylmethyleneamino-β, γ, and δ-lactams from Benzylidene Hydrazines and α, β, γ, and δ-Haloacyl Halides
- Reaction of Biguanides and Related Compounds. XV. Cyclizations of Arylbiguanides and 2-Guanidinobenzimidazole with Bifunctional Unsaturated Dicarboxylates to s-Triazines and Imidazolines
- Behavior of Sulfinic Acid toward N-Chloramines and Related Compounds
- Facile Formation of 1,3-Disubstituted 2,3,5,6-Tetrahydro-2-thioxopyrimidin-4 (1H)-ones and 2-N, 3-Disubstituted 2,3,5,6-Tetrahyro-2-imino-1,3-thiazin-4-ones from Thioureas and β-Haloacyl Halides
- Convenient One-pot Syntheses of Sulfinates, Sulfinamides, and Thiosulfinates by Sulfinylation with p-Toluenesulfinic Acid and Activating Reagents
- A One-Pot Synthesis of β-Lactams by the Reaction of β-Haloacyl Chlorides with α-Amino Acids
- Convenient Syntheses of Cyclic Carboxamides from α, β, γ, δ and ε-Halocarboxamides under Phase Transfer Conditions
- Direct Conversion of Sulfinic Acid to Sulfonic Acid Derivatives
- Thermal Dimerization of Sulfinyl Compounds
- Novel One-step Preparation of Sulfinic Acid Derivatives from Sulfinic Acid
- Asymmetric Synthesis of β-Amino-α, α-dimethyl-β-phenylpropionic Acid. The Reactions of Chiral Schiff Bases with Dimethylketene and with Reformatsky Reagent
- Asymmetric Syntheses of β-Amino Acids by the Reduction of Enamines
- Reaction of Epoxides. VI. Reaction of 2,3-Epoxypropyl Aryl Ether with Ethyl-N-phenylformimidate and N, N'-Diphenylformamidine
- Reaction of Biguanides and Related Compounds. XIV. Cyclization of Amidinothioureas with Some Carbonyl Compounds
- Asymmetric Syntheses of β-Amino Acid and Aspartic Acid by Reformatsky Reaction
- Asymmetric Syntheses of β-Amino Acids by the Addition of Chiral Amines to C=C Double Bonds
- Behaviors of N-(Substituted thio) phthalimides, N-(Substituted thio)-succinimides, and N-(Substituted thio) isatins toward Some Nucleophiles
- Reaction of Biguanides and Related Compounds. XIII. Benzilic Acid Rearrangement. The Reactions of 1,2-Cyclohexanedione and 9,10-Phenanthrenequinone with Arylbiguanides and N-Amidino-0-alkylisoureas
- Conversion of Bis (β-carbamoylethyl) Disulfides into Bis (β-carbamoylethyl) Trisulfides
- Reaction of Biguanides and Related Compounds. XII. Condensations of Arylbiguanides and Amidinoisoureas with Isatins
- Pyrazolines and Oxazolines. Reaction of Arylcarbonylethylthiosulfates with Hydrazines and Hydroxylamines
- Reaction of Epoxides. V. 1,3-Dipolar Cycloaddition Reaction of Epoxides with Carbon-Nitrogen Double Bond Compounds
- Reaction of Biguanides and Related Compounds. X. Formation of s-Triazinethiones by the Condensation of Arylbiguanides with 2,3-Trithiocarbonates
- Thiation of Enamine of Cyclohexanone with Arensulfenamides
- Reaction of Biguanides and Related Compounds. IX. Condensation of N-Amidino-O-alkylisourea and 1-Substituted 3-Amidino-2-thiourea with Benzil
- Reaction of Biguanides and Related Compounds. VIII. The Condensation of Arylbiguanides and N-Amidino-O-alkylisoureas with Diketene and Ethyl Acetoacetate
- The Reaction of Benzyl Phenylmethanethiosulfinate with Amines
- Reaction of Epoxides. IV. Addition of 2,3-Epoxypropyl Phenyl Ether to Oximes and Hydrazones
- Criss-cross Cycloaddition of Epoxides to Aromatic Aldazines
- Arylthiation of Cyclohexanone Morpholine Enamine with Aryl Benzenethiosulfonates
- A Convenient Synthesis of Pyrazolines from β-Carbonylethylthiosulfates
- Reaction of Biguanides and Related Compounds. VII. The Condensation of Arylbiguanide with α, β-Unsaturated Carboxylic Ester in Dimethylformamide
- Reactions of β-Carbonylethylthiosulfates and β-Carbamoylethyl Disulfides with Amines
- Reaction of Biguanides and Related Compounds. VI. Condensation of N-Amidino-O-alkylisourea with β-Diketone
- Sulfenylation of Morpholine Enamine of Cyclohexanone with Sulfenamides and Thiosulfonates
- Mechanism for the Reaction of Sodium Benzylthiosulfate with Morpholine
- Antiviral Effect and Syntheses of 4-Amino-6-alkylamino-s-triazine-2-carboxylic Acid Derivatives. Researches on Chemotherapeutic Drugs against Viruses. XXXVI.
- Syntheses of Compounds related to Guanidine and their Inhibitory Action on Growth of HeLa Cells.
- Reaction of Epoxides. II. Synthesis of Oxazolidine by the Reaction of Epoxide with Schiff Base
- Studies on Antitumor Substances. XII. Synthesis of Bis (2,3-epoxypropyl) amine Derivatives and the Reaction with Some Nucleophiles
- Reactions of Epoxides. I. Synthesis of Trithiocarbonate by the Reaction of Epoxide with Alkali Xanthate
- Studies on Antitumor Substances. XI. Reactions of Bunte Salts with Nucleophiles
- Formation of Trisulfide from Thiosulfonate with Amine Catalyst
- Reaction of Disulfide and Trisulfide with N-Chlorocarboxamide
- Reaction of Biguanides and Related Compounds. III. Reaction of Biguanide and Amidinoisourea with Oxamate
- Reaction of Biguanides and Related Compounds. II. Reaction of Biguanides with Benzil
- Reaction of Biguanides and Related Compounds. I. Reaction of Biguanides with β-Diketone
- Studies on Antitumor Substances. XIII. Reaction of Sodium Ethoxycarbonylmethylthiosulfate and Sodium Phenacylthiosulfate with Amine
- Reaction of N-Amidinoamidine with Diethyl Oxalate and Ethyl Oxamate
- Studies on Application of Amino Acid as Medicinal Agent. II. Reaction of Amino Acid Ester with Difunctional Grignard Reagent
- Studies on Antitumor Substances. X. Reactions of Thiosulfonates with Some Nucleophilic Compounds
- Studies on Antitumor Substances. IX. Chemical Behaviors of Thiosulfonate toward Active Methylene Compound
- Studies on Antitumor Substances. VIII. Syntheses of 4-Amino-6-substituted Amino-2-substituted sym-Triazine Derivatives
- Studies on Application of Amino Acid as Medicinal Agent. I. Syntheses of Amino-tert-alcohol Derivatives
- Reaction of Epoxides. III. The Synthesis of 2-Amino-5-substituted 4,5-Dihydrothiophene from Substituted Propylene Sulfides and Ethyl Cyanoacetate
- Reaction of Biguanides and Related Compounds. V. The Base-catalyzed Condensation of Benzil with 1,1-Dialkylguanidine
- Reaction of Cyclic Trithiocarbonate with Amine and Phenylhydrazine
- Reaction of Biguanides and Related Compounds. IV. Reaction of Arylbiguanide with Benzoylacetone in the Presence of a Small Amount of the Arylbiguanide Hydrochloride
- A Stereoselective Synthesis of α-Chloro-α-phenylacetamide by the Reaction of optically Active Schiff Base with Dichlorocarbene
- The Conversion of α-Carbonylmethylthiosulfates into Thiocarboxamides
- Antitumor Effects of Pentamethylene Bismethanethiosulfonate Hydrolysates and Difunctional Bunte Salt
- Syntheses and Antiviral Effects of 3-Amino-6-alkyl-as-triazin-5-ol Derivatives.
- Syntheses of 4,6-Diamino-s-triazine-2-carboxamide Derivatives.
- Researches on Chemotherapeutic Drugs Against Viruses. XXXV. Syntheses and Antiviral Activity of Alkylated Ephedrine and its Related Compounds.
- Reaction of 1-Arylbiguanide with Some Carboxylic Esters.
- Studies on Syntheses of Dimethylated Ephedrine Derivatives.
- On the Hypoglycemic Activity of Protease Preparation of Streptomyces griseus, Pronase P
- Influence of Quinone Derivatives on Insulin, Glucagon, and Insulinase. IV. Interaction of Insulin with Quinone.
- Studies on Antitumor Substances. III. Syntheses of Bis(methanesulphonylthio)alkanes