Studies on Antitumor Substances. XI. Reactions of Bunte Salts with Nucleophiles

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概要

• 論文の詳細を見る

• In order to examine the relationship between the carcinostatic activities of Bunte salts and their chemical behaviours, several Bunte salts, in which some of them were difunctional, were synthesized and attempted to react with several active methylene compounds, thiols and amines. In the reactions with thiols and amines, all of the Bunte salts resulted in the formation of the corresponding disulfides or the recovery of the starting materials. But in the reaction with active methylene compounds, alkylmercapto or bisalkylmercapto derivatives and cyclic mercaptal were formed respectively.

• 公益社団法人日本薬学会の論文
• 1971-08-25

著者

• 古川 潮

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 林 清五郎

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 藤野 洋子

  Institute for Medical and Dental Engineering, Tokyo Medical and Dental University

• 藤野 洋子

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 中尾 達

  Yoshitomi Seiyaku Co. Ltd.

• 藤野 洋子

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• 井上 誠一

  Sumitomo Kagaku Co., Ltd.

• 林清 五郎

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 井上 誠一

  Sumitomo Kagaku Co. Ltd.

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