Pyrazolines and Oxazolines. Reaction of Arylcarbonylethylthiosulfates with Hydrazines and Hydroxylamines
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概要
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The reactions of arylcarbonylethylthiosulfates (I) with hydrazines and hydroxylamines were investigated. The compound I reacted with phenylhydrazine to give 1-phenyl-3-aryl-2-pyrazolines (II). The reaction of I with hydrazine, however, gave 1-β-arylcarbonylethyl-3-aryl-2-pyrazolines (III). On the other hand, in the reaction of I with N, N-dimethylhydrazine, demethylation occurred to afford 1-methyl-3-aryl-2-pyrazolines (IV). In the reaction of I with hydroxylamine, 3-aryl-2-isoxazolines (V) and β, β'-hydroxylamino-bis-propiophenones (VI) were obtained under refluxing conditions and at room temperature, respectively. Moreover, the reaction of I with phenylhydroxylamine gave N-arylcarbonylethylhydroxylamines (VIII).
- 公益社団法人日本薬学会の論文
- 1974-09-25
著者
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古川 潮
Faculty Of Pharmaceutical Sciences Kumamoto University
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林 清五郎
Faculty Of Pharmaceutical Sciences Kumamoto University
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幸 健
Faculty of Pharmaceutical Sciences, Kumamoto University
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幸 健
Faculty Of Pharmaceutical Sciences Kumamoto University
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林清 五郎
Faculty Of Pharmaceutical Sciences Kumamoto University
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