Reaction of Disulfide and Trisulfide with N-Chlorocarboxamide

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概要

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• The reactions of diaryl disulfide with N-chlorosuccinimide, N-chloroacetamide and N-chlorosaccharine were attempted. When diaryl disulfide was allowed to react with N-chlorosuccinimide in the presence of pyridine, N-arylsulfensuccinimide was obtained in moderate yield. The reaction of di (p- and m-nitrophenyl) disulfide with N-chloroacetamide in the similar conditions was also successfully carried out to yield the corresponding N-sulfenacetamide, though dibenzyl disulfide reacted to give exclusively N-sulphidobisacetamide. In the reaction with N-chlorosaccharine, N-sulfensaccharine was successful to isolate only in the case of di (o-nitrophenyl). disulfide. Dibenzyl trisulfides also reacted with N-chlorosuccinimide under the similar conditions to give N-phenyl-methanesulfensuccinimides.

• 公益社団法人日本薬学会の論文
• 1972-09-25

著者

• 古川 潮

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 林 清五郎

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 藤野 洋子

  Institute for Medical and Dental Engineering, Tokyo Medical and Dental University

• 藤野 洋子

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 小島 洋子

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 藤野 洋子

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• 小野 みずほ

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 林清 五郎

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 小野 みずほ

  Faculty Of Pharmaceutical Sciences Kumamoto University

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