A Stereoselective Synthesis of α-Chloro-α-phenylacetamide by the Reaction of optically Active Schiff Base with Dichlorocarbene

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概要

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• Optically active N-benzylidene-R(+)- and S(-)-α-methylbenzylamines (1b, c) were allowed to react with dichlorocarbene to give optically active α-methylbenzylamine-α-chloro-α-phenylacetamides (3b, c), and the ratio of diastereomers was R-R : S-R=73 : 27 and S-S : R-S=79 : 21,respectively.

• 公益社団法人日本薬学会の論文
• 1977-01-25

著者

• 古川 潮

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 大川 原正

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 寺脇 由里子

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 大川 原正

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 寺脇 由里子

  Faculty Of Pharmaceutical Sciences Kumamoto University

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