Syntheses of New Pyrazoline Derivatives

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概要

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• In order to synthesize 1-substituted amino-3,5,5-trimethylpyrazolines, diacetonalcohol was employed as the starting material, from which mesityloxide was prepared by the treatment with a catalytic amount of iodine, followed by the cyclization with hydrazine. The resulting 3,5,5-trimethylpyrazoline was converted to 1-chloroacetyl-3,5,5-trimethylpyrazoline by the reaction with chloroacetylchloride, followed by the reaction with a variety of amine. In this process, the reaction of mesityloxide with hydrazone was deduced to proceed probably through the intermediate of the corresponding hydrazone. Moreover, 1-β-carboethoxyethyl-3,5,5-trimethylpyrazoline was obtained by the reaction of 3,5,5-trimethylpyrazoline with ethyl acrylate.

• 公益社団法人日本薬学会の論文
• 1968-03-25

著者

• 古川 潮

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 林 清五郎

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 西嶋 洋子

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 井上 謙吾

  Pharmaceutical Research and Development Section, Kyowa Hakko Kogyo Co., Ltd.

• 井上 謙吾

  Pharmaceutical Research And Development Section Kyowa Hakko Kogyo Co. Ltd.

• 林清 五郎

  Faculty Of Pharmaceutical Sciences Kumamoto University

関連論文

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