Syntheses of Compounds related to Guanidine and their Inhibitory Action on Growth of HeLa Cells.

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概要

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• To find chemotherapeutic agents for influenza and polio virus and adeno virus, alkylbiguanide, arylbiguanide, 1-aryl-4,6-diamino-1,2-dihydro-1,3,5-triazine, 4-amino-6-arylamino-2-alkyl-1,3,5-triazine, 2,4-diamino-5-alkyl-6-hydroxypyrimidine, and 2,4-diamino-5-aryl-6-alkylpyrimidine were synthesized. In process of the synthesis of these compounds, it was found that the reaction of arylbiguanide with ethyl ester of carboxylic acid afforded, without the presence of alkaline catalyst, 4-amino-6-arylamino-2-alkyl-1,3,5-triazine. None of the compounds of this series showed activity on any of the viruses. Among these compounds, however, butyl-aned hexyl-biguanide and 1-(p-tolyl)-, 1-(o-methoxyphenyl)-, 1-(p-methoxyphenyl)-, 1-(o-ethoxyphenyl)-, and 1-(p-ethoxyphenyl)-4,6-diamino-2,2-dimethyl-1,2-dihydro-1,3,5-triazine had inhibitory action on the growth HeLa cells.

• 公益社団法人日本薬学会の論文
• 1961-11-25

著者

• 古川 潮

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 豊島 滋

  Pharmaceutical Institute, Keio-Gijuku University

• 瀬戸 淑子

  Pharmaceutical Institute, Keio-Gijuku University

• 豊島 滋

  慶大・医学部・薬化学研究所・化学療法部門

• 豊島 滋

  Pharmaceutical Institute Keio-gijuku University

• 古川 潮

  Pharmaceutical Instiute, Keio-Gijuku University

関連論文

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