Researches on Chemotherapeutic Drugs against Viruses. XXIV. Studies on the Syntheses and Antiviral Effect of 2-Alkylphenoxyalkanoic Acids
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概要
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In order to study the antiviral effect of alkanoic acid containing alkylphenoxy group in 2-position, 2-alkylphenoxyacetic, -propionic, -butyric, and -valeric acids were synthesized. By the condensation of alkylphenol with ethyl 2-haloalkanoate, ethyl 2-alkylphenoxy-alkanoate was obtained, which was hydrolysed to 2-alkylphenoxyalkanoic acid. o-Hexylphenoxyacetic acid had antiviral activity against Japanese B encephalitis virus in vivo. Several compounds in this series were found to be effective against the PR-8strain of influenza A virus and the Lansing strain of poliomyelitis virus in vitro.
- 公益社団法人日本薬学会の論文
- 1959-10-20
著者
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上田 武雄
Pharmaceutical Institute, Keio-Gijuku University
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豊島 滋
Pharmaceutical Institute, Keio-Gijuku University
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豊島 滋
慶大・医学部・薬化学研究所・化学療法部門
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豊島 滋
Pharmaceutical Institute Keio-gijuku University
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上田 文雄
Pharmaceutical Institute Keio-gijuku University
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上田 武雄
School Of Pharmaceutical Sciences Kitasato University
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