Synthese de Pyrimidines et de Pyrazoles a partir d'Acyl-3 halogeno-5 benzofurannes
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概要
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En partant des chloro-5 ou bromo-5 salicylaldehydes, nous avons synthetise quatre acyl-3 halogeno-5 benzofurannes : acetyl-3 chloro-5-(1), benzoyl-3 chloro-5-(2), acetyl-3 bromo-5-(3) et benzoyl-3 bromo-5-(4) ethyl-2 benzofurannes. Ces acyl-3 benzofurannes halogenes peuvent etre transformes en (halogeno-5 hydroxy-2 phenyl)-5 pyrimidines, par la guanidine, la thiouree, l'acetamidine et la cyanoguanidine, mais pas par l'uree. On peut classer les aptitudes des reactifs diamines a donner des pyrimidines avec les acyl-3 halogeno-5 benzofurannes dans le meme ordre que celui que nous avions deja releve pour les benzofurannes non-halogenes : guanidine>thiouree>acetamidine≫uree.
- 公益社団法人日本薬学会の論文
- 1975-10-25
著者
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高木 要
Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.
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高木 要
Central Research Laboratories Zeria Pharmaceutical Co. Ltd.
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高木 要
Faculte des Sciences Pharmaceutiques, Universite Kitasato
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上田 武雄
Faculte des Sciences Pharmaceutiques, Universite Kitasato
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上田 武雄
School Of Pharmaceutical Sciences Kitasato University
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