Reaction of Ethoxymethylenemalononitrile with Hydrazine Hydrate
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概要
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The reaction of ethoxymethylenemalononitrile (EMMN) with hydrazine hydrate in the presence of ethanol at room temperature gave 3-amino-4-cyanopyrazole (I) and a novel pyrazole derivative, 3-amino-4-cyano-2-hydrazonomethylpyrazole (II). When this reaction was carried out under reflux, II was not obtained. The result of various solvents for the preparation of II was found at present acetonitrile as a solvent most suitable. The reaction of EMMN with hydrazine hydrate in water at room temperature gave I in good yield. On the other hand, the reaction of hydrazine hydrate with excess EMMN afforded 7-amino-3,6-dicyanopyrazolo [1,5-a] pyrimidine.
- 公益社団法人日本薬学会の論文
- 1976-11-25
著者
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上田 武雄
School of Pharmaceutical Sciences, Kitasato University
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長原 勝彦
School of Pharmaceutical Sciences, Kitasato University
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長原 勝彦
Faculte Des Sciences Pharmaceutiques Universite Kitasato
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高木 要
Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.
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高木 要
Central Research Laboratories Zeria Pharmaceutical Co. Ltd.
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高木 要
School of Pharmaceutical Sciences, Kitasato University
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上田 武雄
School Of Pharmaceutical Sciences Kitasato University
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