Synthesis of 3-(Guaiazulen-3-yl)-3-oxopropionic Acid Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
Guaiazulene (1,4-dimethyl-7-isopropylazulene) reacted with malonyl dichloride in the absence of a Lewis acid to afford 3-(guaiazulen-3-yl)-3-oxopropionylchloride (1), which was converted by treatment with water into 3-(guaiazulen-3-yl)-3-oxopropionic acid (2) and 3-acetylguaiazulene (3). Upon treatment of 1 with some alcohols and aromatic amines, the corresponding esters (4) and amides (5) were obtained, respectively. The reaction of methyl 3-(guaiazulen-3-yl)-3-oxopropionate (4a) with hydrazine gave 3-(guaiazulen-3-yl)-3-oxopropionylhydrazide (6), which was easily cyclized into 5-(guaiazulen-3-yl)-2,3-dihydropyrazol-3-one (7).
- 公益社団法人日本薬学会の論文
- 1980-12-25
著者
-
高木 要
Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.
-
高木 要
Central Research Laboratories Zeria Pharmaceutical Co. Ltd.
-
武藤 泰章
ゼリア新薬工業株式会社中央研究所
-
武藤 泰章
Research Laboratories, Zeria Pharmaceutical Co., Ltd.
-
市川 弘美
Research Laboratories, Zeria Pharmaceutical Co., Ltd.
-
高木 要
Research Laboratories, Zeria Pharmaceutical Co., Ltd.
-
市川 弘美
Research Laboratories Zeria Pharmaceutical Co. Ltd.
関連論文
- Sur les Possibilites de Formation de Pyrimidines a partir de la Dibromo-3,4 dihydro-3,4 coumarine
- Synthesis of New Pyrimidine Derivatives from 2-Methyl-3-nitro- and 3-Amino-2-methylchromones
- Synthesis and Some Reactions of 6- (2-Hydroxyphenyl) -2-thiouracils
- Synthesis of Bisfurazanobenzo-2,1,3-thiadiazole and Related Compounds
- Synthesis and Reaction of Furazanobenzothiadiazole and Related Compounds
- イソタコフォレシスによるローヤルゼリー中の10-Hydroxy-Δ^2-decenoic Acidの定量
- 抗潰瘍剤の研究(第4報)Phenylpropanol誘導体の合成と抗潰瘍作用
- 抗潰瘍剤の研究(第3報)Phenylpropanol誘導体の合成と抗潰瘍作用
- 抗潰瘍剤の研究(第2報)Phenylpropanol誘導体の合成と抗潰瘍作用
- 抗潰瘍剤の研究(第1報)各種生薬のメタノール及び水抽出エキスの抗潰瘍作用
- Ring Transformation of 4-Amino-1H-1,5-benzodiazepine-3-carbonitrile. II. Formation of Ring-opened Hydrazine Adducts
- Ring Transformation of 4-Amino-1H-1,5-benzodiazepine-3-carbonitrile. The Use of Hydroxylamines as Nucleophile
- Reaction of Ethoxymethylenemalononitrile with 2-Aminopyridines
- Reaction of Ethoxymethylenemalononitrile with Hydrazine Hydrate
- Reaction of ο-Aminobenzamide Derivatives with Ethoxymethylenemalononitrile and Its Analogue
- Sur la Transformation de Derives Oxadiazoliques en Oxo-4 quinazolines par Hydrogenation Catalytique
- Sur la Formation d'Oxadiazoles-1,2,4 par Action de Benzamidoximes sur des Anhydrides Isatoiques
- Sur la Formation d'un Derive Pyrazolique Original a partir d'Hydrazine et d'Ethoxymethylene Malononitrile
- Synthesis of 3-(Guaiazulen-3-yl)-3-oxopropionic Acid Derivatives
- Synthese de Pyrimidines et de Pyrazoles a partir d'Acyl-3 halogeno-5 benzofurannes
- Sur Quelques Proprietes du Phenyl-2 formyl-3 benzofuranne
- Etude de la Reactivite d'Oxo-4 tetrahydro-4,5,6,7 benzofurannes. III. Sur la Formation de Furoacridines a partir du p-Bromophenyl-2 oxo-4 tetrahydro-4,5,6,7 benzofuranne
- Etude de la Reactivite d'Oxo-4 tetrahydro-4,5,6,7 benzofurannes. II. Acces aux Furoacridines par Application de la Reaction de Friedlaender
- Etude de la Reactivite d'Oxo-4 tetrahydro-4,5,6,7 benzofurannes. I. Acces aux Furo [2,3-c]-acridines par Condensation de 1'Isatine et de 1'Acide Anthranilique
- Sur la Formation des 8-Triazines par Action de Biguanides sur l'Ethoxymethylene Acetoacetate d'Ethyle ou sur l'Ethoxymethylene Malonate d'Ethyle
- Syntheses and Antiviral Effect of (Amidinocarbamoyl) pyridine Derivatives
- Reaction of 1-Substituted Biguanide with Diethyl Formylsuccinate and Diethyl Succinate.
- Syntheses of Pyrimidinylhydrazones of 4-Biphenylylglyoxal