抗潰瘍剤の研究(第1報)各種生薬のメタノール及び水抽出エキスの抗潰瘍作用
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概要
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The antiulcer activities of 59 methanol and aqueous extracts obtained from 59 crude drugs on the ethanol-HCl-induced ulceration in rats were investigated. Among them 15 extracts were selected and they were further examined for their effects on indomethacin-, aspirin- and the water-immersion stress-induced ulcer. From these results, the methanol extract of root of Iris germanica was found to show potent antiulcer activities. The above methanol extract was separated into 3 portions by solvent extration, and the ether soluble portion was fractionated into 5 fractions (1 to 5) by chromatography. Fractions 4 and 5 showed significant antiulcer activities. Fraction 4 was further purified and the obtained γ-irigermanal exhibited a potent antiulcer activity. However, further investigations are required to understand the mechanism.
- 公益社団法人日本薬学会の論文
- 1994-12-25
著者
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白瀧 義明
城西大学
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横江 一朗
城西大学薬学部
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小川 悦男
ゼリア新薬工業(株)
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渡辺 正直
ゼリア新薬工業株式会社中央研究所
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白瀧 義明
城西大学薬学部
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Yokote Yoshiko
城西大学理学部
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武藤 〓章
ゼリア新薬工業株式会社中央研究所
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小松 曼耆
城西大学薬学部
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武藤 泰章
ゼリア新薬工業株式会社中央研究所
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市川 弘美
ゼリア新薬工業株式会社中央研究所
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清木 雅雄
ゼリア新薬工業株式会社中央研究所
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北川 治
ゼリア新薬工業株式会社中央研究所
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熊谷 一紘
ゼリア新薬工業株式会社中央研究所
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小川 悦男
ゼリア新薬工業株式会社中央研究所
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清木 雅雄
ゼリア新薬工業 (株) 中央研究所
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