銅によるタンパク質の酸化的修飾に対するマメ科植物中から単離されたdl-α-puerolの抑制作用
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概要
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マメ科植物中から単離されたdl-α-puerolは、but-2-enolideの一つである。従来から、マメ科植物由来の生薬には抗酸化性のあることが認められている。その抗酸化成分は、ポリフェノールやフラボノイドがほとんどである。今回、dl-α-puerolに酸化的ストレスの一種である銅によるタンパク質の酸化的修飾を抑制する作用のあることが認められた。このことは、従来から認められてきたポリフェノールやフラボノイド以外の荷も、酸化的ストレス障害を抑制する作用のあることを示唆するものである。
- 関西医療大学の論文
著者
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白瀧 義明
城西大学
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白瀧 義明
Faculty of Pharmaceutical Sciences, Josai University
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戸田 静男
Department of Pharmaceutical Science, Kansai College of Oriental Medicine
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