抗潰瘍剤の研究(第4報)Phenylpropanol誘導体の合成と抗潰瘍作用
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概要
- 論文の詳細を見る
It was found that (±) ethyl 2-[2-(3-hydroxypropyl)-4-oxocyclohexylidene]-propionate (1), (±) ethyl 2-[2-(3-hydroxypropyl)-4,5-dimethoxyphenyl] propionate (2), (±) 3-[2-(3-hydroxypropyl)-4,5-dimethoxyphenyl]-2-butanone (3) and (±) 2-[2-(3-hyroxypropyl)-4-methoxy-5-(2-piperidinoethoxy) phenyl] cyclopentanone (4) had potent antiulcer activities. In order to study structure-activity relationships, (±) 3-[(3-hydroxypropyl) phenoxy]-2-butanone derivatives (5,6) were synthesized and tested for antiulcer activities. Among them, (±) 3-[2-(3-hydroxypropyl)-4-methoxy-5-[3-(4-methylpiperidino) propoxy] phenoxy]-2-butanone・3/2 oxalate (6k) was selected as a preferred antiulcer agent.
- 公益社団法人日本薬学会の論文
- 1995-04-25
著者
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白瀧 義明
城西大学
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横江 一朗
城西大学薬学部
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白瀧 義明
城西大学薬学部
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Yokote Yoshiko
城西大学理学部
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Chakrabarty A.
Department Of Medical Microbiology And Parasitology Calcuttauniversity College Of Medicine
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小松 曼耆
城西大学薬学部
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武藤 泰章
ゼリア新薬工業株式会社中央研究所
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市川 弘美
ゼリア新薬工業株式会社中央研究所
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清木 雅雄
ゼリア新薬工業株式会社中央研究所
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清木 雅雄
ゼリア新薬工業 (株) 中央研究所
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