抗潰瘍剤の研究(第2報)Phenylpropanol誘導体の合成と抗潰瘍作用
スポンサーリンク
概要
- 論文の詳細を見る
It was found that γ-irigermanal, obtained from the methanol extract of root of Iris germanica, exhibited a potent antiulcer activity. Therefore, this compound was selected as a lead-compound, and related compounds were synthesized and tested for antiulcer activities. It was found that (±) ethyl 2-[2-(3-hydroxypropyl)-4-oxocyclohexylidene]-propionate (1) had excellent antiulcer activities. Then phenylpropanol derivatives, obtained by changing from cyclohexane ring of 1 to benzene ring, were synthesized and tested for antiulcer activities in order to study structure-activity relationships. As a result, (±) ethyl 2-[2-(3-hydroxypropyl)-4,5-dimethoxyphenyl] propionate (2b) and (±) 3-[2-(3-hydroxypropyl)-4,5-dimethoxyphenyl]-2-butanone (5) were shown to have antiulcer activities.
- 公益社団法人日本薬学会の論文
- 1994-12-25
著者
-
横江 一朗
城西大学薬学部
-
白瀧 義明
城西大学薬学部
-
Yokote Yoshiko
城西大学理学部
-
武藤 〓章
ゼリア新薬工業株式会社中央研究所
-
小松 曼耆
城西大学薬学部
-
武藤 泰章
ゼリア新薬工業株式会社中央研究所
-
市川 弘美
ゼリア新薬工業株式会社中央研究所
-
清木 雅雄
ゼリア新薬工業株式会社中央研究所
-
清木 雅雄
ゼリア新薬工業 (株) 中央研究所
関連論文
- Biological activity of persimmon (Diospyros kaki) peel extracts
- Inhibition of LPS-stimulated NO production in mouse macrophage-like cells by Barbados cherry, a fruit of Malpighia emarginata DC
- Relationship between Cytotoxic Activity and Radical Intensityof Isoflavones from Sophora Species
- In Vitro Biological Activity of Prenylflavanones
- Biological activity of a fruit vegetable, "Anastasia Green", aspecies of sweet pepper
- Biological activity of Kiwifruit peel extracts
- Changes in Intracellular Concentration of Amino Acids andPolyamines during the Apoptosis of HL-60 Cells
- Biological Activity of Feijoa Peel Extracts
- Selective Cytotoxic Activity of Grape Peel and Seed ExtractsAgainst Oral Tumor Cell Lines
- Cytotoxic and Multidrug Resistance Reversal Activity of a Vegetable, `Anastasia Red', a Variety of Sweet Pepper
- Effects of Isoflavones from Sophora Species on the Growth and Activation of a Mouse Macrophage-like Cell Line
- Cancer prevention and therapy with kiwifruit in Chinese folklore medicine: a study of kiwifruit extracts
- Effects of Prenylflavanones from Sophora Species on Growth and Activation of Mouse Macrophage-like Cell line
- Antioxidative Activty of Allium victarialis L. Extracts
- Cytotoxic Activity of 2-Aminomethylene-3(2H)-benzofuranones against Human Oral Tumor Cell Lines
- Cytotoxic Activity of Benzothiepins against HumanOral Tumor Cell Lines
- Cytotoxic Activity of 5-Benzoylimidazole and RelatedCompounds against Human Oral Tumor Cell Lines
- Radical Modulating Activity and Cytotoxic Activity ofSynthesized Eugenol-Related Compounds
- Effects of Anticancer Drugs, Metals and Antioxidantson Cytotoxic Activity of Benzothiepins/Benzoxepins
- Cytotoxicity and Radical Intensity of Eugenol, Isoeugenolor Related Dimers
- Radical Intensity and Cytotoxicity of Butylated Hydroxyanisoleand its Orthobisphenol Dimer
- Flavonoids as Inhibitors of MRP1-like Efflux Activity in Human Erythrocytes.A Structure-Activity Relationship Study
- Differential interaction of Sophora isoflavonoids with lipid bilayers
- Lipid Membrane Perturbation Caused by Some Isoflavones and Phenothiazines, and The Activity of These Compounds as Inhibitors of Multidrug Resistance
- Antimicrobial Activity of Prenylflavanones
- Monitoring of MRP-like Activity in Human Erythrocytes :Inhibitory Effect of Isoflavones
- Lewis Acid-Promoted Cycloaddition Reaction ofCyclopropanes with Allylsilanes
- Synthesis of 4-Oxepanones by the Lewis Acid-PromotedRing-Expansion Reaction of Cyclopropapyranones
- Lewis Acid-Mediated Ring Expansion Reaction of Benzo[b]cyclopropa[e]pyran-7-ol Acetates: Facile Synthesis of2-Alkyl Substituted 2,3-Dihydro-1-benzoxepins
- Lewis Acid-Mediated Ring Expansion Reaction of 2,3-Metanochromanones with Silyl Enol Ethers
- Inhibition of Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase by Flavonoids. III
- New resveratrol oligomers in the stem bark of Vatica pauciflora
- Diastereoselective Ring-Expansion Reaction of Methanochromanone with Aldehydes: Formation of trans-FusedTetrahydrofuro[2,3-b][1]benzopyranones and TheirIsomerization
- Synthesis of Tetrahydrofuro[2,3-b][1]benzopyranones bythe Ring-Expansion Reaction of Methanochromanone withSymmetric Ketones
- rhaponticinの銅脂質過酸化に対する抑制作用
- Relationship between Radical Intensity and BiologicalActivity of Cacao Husk Extracts
- (平成12年度学長所管 研究テーマ) 「胃潰瘍原因菌 : Helicobacter pylori のラットへの感染に関する基礎的検討、並びに抗菌物質の探索」
- Four isoflavanones from roots of Sophora tetraptera
- Four Isoflavones from Roots of Sophora tetraptera.
- Isoflavonoids from Sophora secundiflora, S. Arizonica and S. Gypsophila.
- Isoflavanones in Roots of Sophora secundiflora.
- 抗潰瘍剤の研究(第4報)Phenylpropanol誘導体の合成と抗潰瘍作用
- 抗潰瘍剤の研究(第3報)Phenylpropanol誘導体の合成と抗潰瘍作用
- 抗潰瘍剤の研究(第2報)Phenylpropanol誘導体の合成と抗潰瘍作用
- 抗潰瘍剤の研究(第1報)各種生薬のメタノール及び水抽出エキスの抗潰瘍作用
- 生薬成分イソフラボノイドの活性酸素消去作用について(鍼灸基礎)
- Two Flavanones in Sophora leachiana and Some Related Structures
- Sophoraflavanones H, I and J, Flavonostilbenes from Sophora moorcroftiana
- Studies on the Constituents of Sophora Species. XXIII. : Constituents of the Root of Sphora chrysophylla SEEM. (1)
- Studies on the Constituents of Sophora Species. XXII. : Constituents of the Root of Sophora moorcroftiang BENTH. ex BAKER. (1)
- SOPHORASIDE A, A NEW AROMATIC GLYCOSIDE FROM THE ROOTS OP SOPHORA JAPONICA(Communications to the Editor)
- DETERMINATION OF C-6 OR C-8 SUBSTITUTED FLAVANONE USING ^C-^1H LONG RANGE COUPLING AND THE REVISED STRUCTURES OF SOME FLAVANONES
- シュッコンハゼランの成分研究(第1報)
- 4-(2-Aminoethylamino)-7H-benz[de]benzimidazo[2,1-a]isoquinoline-7-one as a Highly Sensitive Fluorescent LabelingReagent for Carnitine
- Phylogenetic Analysis of Carotenoid-Producing Marine Microorganisms Around the Coral Reefs of the Kerama Islands of Okinawa
- Antibacterial Activity of Stilbene Oligomers against Vancomycin-Resistant Enterococci (VRE) and Methicillin-Resistant Staphylococcus aureus (MRSA) and Their Synergism with Antibiotics
- A Monoterpene Glucoside and Three Megastigmane Glycosides from Juniperus communis var. depressa
- Stilbene Oligomers in Roots of Sophora moorcroftiana
- Stilbene Derivatives from Two Species of Gnetaceae
- Four New Glucosides of Stilbene Oligomers from theStem of Gnetum gnemonoides
- Stilbenoids in Lianas of Gnetum parvifolium
- Three New Trimeric Stilbenes from Gnetum gnemon
- Stilbene Oligomers in Roots of Sophora moorcroftiana
- Four New Glucosides of Stilbene Oligomers From the Stem of Gnetum gnemonoides.
- Inhibitory Effect of Plant Extracts on Production of Verotoxin by Enterohemorrhagic Escherichia coli 0157 : H7.
- Stilbenoid in Lianas of Gnetum parvifolium.
- Stilbene Derivatives from Two Species of Gnetaceae
- Three New Trimeric Stilbenes from Gnetum gnemon.
- Six Flavonostilbenes from Gnetum africanum and Gnetum gnemon
- Sophora属植物の成分研究(第10報) エンジュ根の成分その1
- Functional baioactivity of Polygonatum species
- Eugenol関連化合物の二量体化と細胞傷害性
- Inhibitory Effects of Isoflavones in Sophora moorcroftiana on Lipid Peroxidation by Superoxide
- Antioxidative effects of Dibenzo-α-pyrones in Fruits ofTrapa natans on Lipid Peroxidation
- Inhibitory Effects of Echinoisoflavanone and SophoraisoflavanoneD in Sophora chrysophylla Seem on Lipid Peroxidation of MiceBrain Homogenate by Interaction of Ferrous Ion and HydrogenPeroxide In Vitro
- Reaction of 3-Iodochromone with Nucleophiles 3.Formation of 2-Aminomethylene-3(2H)-benzofuranonesby the Reaction with Secondary Amines
- Synthesis of Trisubstituted 4-Oxepanones by theLewis Acid-Promoted Three-Component Ring-ExpansionReaction of Cyclopropapyranones, Silyl Enolates andGlyoxylates
- Reaction of 3-Iodochromone with Nucleophiles 2. Reactionwith Mercaptoazoles
- Synthesis of Tetrahydrofurans by the Reaction of α,β-Epoxy Alcohol Derivatives with Allylsilanes
- Anti-VRE and Anti-MRSA Activities of New Quinolones and Their Synergism with Commercial Antibiotics. Part 2
- Mechanical Properties and Antibacterial Efficacy of Chitosan Films
- Activities of Novel New Quinolone Compounds against Vancomycin-Resistant Enterococci and Methicillin-Resistant Staphylococcus aureus and Their Synergism with Several Antibiotics
- Effects of Laundering and Light-Exposure on the Antimicrobial Activity of Cotton Fabrics Finished with Metal Salts
- P-83 Sophoraflavanone B,Hの酸化的ストレス障害に対する抑制作用
- 28D-03 Isoflavone および Isoflavone glycoside の脂質過酸化抑制作用
- 4-(2-Aminoethylamino)-7H-benz[de]benzimidazo[2,1-a]isoquinoline-7-one as a Highly Sensitive Fluorescent Labeling Reagent for Carnitine
- Dibenzo-α-pyrones in fruits of Trapa natans
- Inhibitory Effects of Astragali Radix, Crude Drug in OrientalMedicines on Lipid Peroxidation and Protein Oxidative Modificationof Mouse Brain Homogenate by Copper
- Novel Isocoumarin Derivatives from Achlys triphylla(Berberidaceae)
- Stilbene Oligomers in Roots of Sophora moorcroftiana
- Comparison of Antioxidative and Chelating Effects of Daidzeinand Daidzin on Protein Oxidative Modification by Copper In Vitro
- Inhibitory Effect of Sophoraflavanone H in Sophora moorcroftianaBenth ex Baker, a Crude Drug, on Lipid peroxidation in vitro
- Antioxidative Effects of Daidzein and Daidzin, Isoflavonoids inAstragali Radix, on Lipid Peroxidation of Mice Brain Homogenateby Copper in Vitro
- Inhibitory Effects of Sophoraflavanones B and H in Sophoramoorcroftiana Benth ex Baker on Copper-Ion-Induced ProteinOxidative Modification of Mice Brain Homogenate In Vitro
- Comparisons of the Inhibitory Effects of Genistein andGenistin on Lipid Peroxidation of Brain Homogenate in vitro
- Comparisons of Antioxidative and Chelating Effects ofDaidzein and Daidzin
- Inhibitory effects of Astragali Radix, a crude drug in Orientalmedicines, on lipid peroxidation and protein oxidative modification by copper
- Inhibitory Effects of Isoflavones on Lipid Peroxidation byOxygen Species
- Application of bis-eugenol to a zinc oxide eugenol cement
- 酸化防止作用をもつ植物成分