Ring Transformation of 4-Amino-1H-1,5-benzodiazepine-3-carbonitrile. II. Formation of Ring-opened Hydrazine Adducts
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概要
- 論文の詳細を見る
Hydrazines readily reacted with 4-amino-1H-1,5-benzodiazepine-3-carbonitrile (1) to afford ring-opened hydrazine adducts (2) which were recyclized to compounds 3,4 and 9 by treatment with aqueous sodium hydroxide solution. Compound 4 was converted to 5 by loss of ammonia in good yield. All the reactions described here were carried out in water.
- 公益社団法人日本薬学会の論文
- 1983-06-25
著者
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岡本 義久
School of Pharmaceutical Sciences, Kitasato University
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上田 武雄
School of Pharmaceutical Sciences, Kitasato University
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高木 要
Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.
-
岡本 義久
School Of Pharmaceutical Sciences Kitasato University
-
高木 要
Central Research Laboratories Zeria Pharmaceutical Co. Ltd.
-
高木 要
Zeria Pharmaceutical Co.
-
上田 武雄
School Of Pharmaceutical Sciences Kitasato University
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