Fluorometric Determination of Hydrogen Peroxide with 4-Amino-1H-1,5-benzodiazepine-3-carbonitrile Hydrochloride
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概要
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The ring transformation reaction of nonfluorescent 4-amino-1H-1,5-benzodiazepine-3-carbonitrile hydrochloride (1) with hydrogen peroxide to fluorescent benzimidazole was applied for the determination of hydrogen peroxide by fluorometry. Peroxidase was employed as a catalyst in the reaction. The measurable range was from 5.880×10^<-7> mol/l to 1.176×10^<-5> mol/l of hydrogen peroxide. Although the detection limit is not as good as that with diacetyldichlorofluorescin (detection limit of about 10^<-8> mol/l), 1 has the advantages of better solubility in water and stability against oxidation by air.
- 公益社団法人日本薬学会の論文
- 1980-08-25
著者
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木下 俊夫
School of Pharmaceutical Sciences, Kitasato University
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岡本 義久
School of Pharmaceutical Sciences, Kitasato University
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岡本 義久
School Of Pharmaceutical Sciences Kitasato University
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稲益 左知子
School of Pharmaceutical Sciences, Kitasato University
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稲益 左知子
School Of Pharmaceutical Sciences Kitasato University:(present Address)faculty Of Hygienic Sciences
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木下 俊夫
School Of Pharmaceutical Sciences Kitasato University
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