Syntheses of 2-Acylaminoacetamidine and 3-Acylaminopropionamidine Derivatives
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概要
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For the purpose to examine as to their antiviral activities, 2-acylaminoacetamidine (II) and 3-acylaminopropionamidine hydrochlorides (III) were synthesized from the corresponding nitriles via ethyl imidates. The difference of the reactivity between ethyl 2-acylaminoacetimidates and ethyl 3-acylaminopropionimidates on the course of amidination were postulated. Iminoesterification of dinitrile, (p-cyano) benzamidopropionitrile (XVIII), was discussed by referring the infrared spectrum of a corresponding monocyanomonoester, ethyl p-(N-cyanoethylcarbamoyl) benzoate (XXI). Among the compounds obtained hereof, 3-(p-methyl) benzamidopropionamidine hydrochloride was found to have an inhibitory effect on influenza virus in mice and in membrane culture.
- 公益社団法人日本薬学会の論文
- 1968-12-25
著者
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岡本 義久
School of Pharmaceutical Sciences, Kitasato University
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上田 武雄
College of Pharmaceutical Sciences, Kitasato University
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岡本 義久
School Of Pharmaceutical Sciences Kitasato University
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村岡 全子
Department Of Chemistry Japan Women's University
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岡本 義久
Pharmaceutical Institute, Keio Gijuku University
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村岡 全子
Japan Women's University
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辻 忠和
Department Of Chemistry Japan Women's University
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