Syntheses of 3-Sulfonamidopropionamidine Derivatives

概要

論文の詳細を見る
A series of thirty-one sulfonamidopropionamidine derivatives have been synthesized and evaluated for antiviral activity. The synthesis of the sulfonamidopropionamidine series was prepared from the corresponding nitriles via ethyl imidates. The compounds synthesized were tested as to their inhibitory effect on polio virus in membrance culture and influenza virus in mice. The results of testing these compounds were found ineffective on the polio virus. However, among the intermediate nitrile derivatives, three compounds, 11,12 and 22,exerted slight effect and final amidine derivatives, five compounds, 7,8,11,18 and 19,showed marked effects on the influenza virus in mice. Especially, 3-(4-ethylbenzenesulfonamido) propionamidine hydrochloride (7) was found comparable to that of Adamantanamine Hydrochloride.
公益社団法人日本薬学会の論文
1969-10-25