Alkylated Pyrimidine Derivatives as Antiviral Agents. I. Syntheses and Antiviral Screening of Alkylpyrimidine and 5-Alkyluracil Nucleoside

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概要

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• In order to find the effective antiviral agents, 5-alkyluracil, 3-alkyluracil, 5-alkylisocytosine, 5-alkyl-6-methylisocytosine, 3-alkyl-6-methyluracil, 5-alkyluracil-1-β-D-glucopyranoside and 5-alkyluracil-1-β-D-ribofuranoside were synthesized and screened as to their antiviral effect on both RNA and DNA containing viruses. For RNA viruses, type-1 Mahoney strain of polio virus and K-2211 strain of ECHO-28 virus were used. For DNA viruses, type-1 and type-12 strains of adeno virus and DV-96 strain of Vaccinia virus were used. Among these tested compounds, 5-butyluracil and 5-butyluracil-1-β-D-ribofuranoside were found to possess effect on both RNA and DNA viruses. Especially, the latter was more effective than the former. Moreover, the latter exerted a broader antiviral spectrum than that of 5-fluorodeoxyuridine.

• 公益社団法人日本薬学会の論文
• 1970-02-25

著者

• 高田 純

  北里大(薬)

• 上田 武雄

  College of Pharmaceutical Sciences, Kitasato University

• 村岡 全子

  Department Of Chemistry Japan Women's University

• 上田 武雄

  School Of Pharmaceutical Sciences Kitasato University

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