Synthesis of 2-Substituted-6-amino-4,5-dihydropyrimidine
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概要
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The convenient synthesis of 2-substituted-6-amino-4,5-dihydropyrimidine from the reaction of imidic ester with 3-aminopropionitrile was reported. Next, 2-phenyl- (V) and 2-(2-acylaminoethyl)-6-amino-4,5-dihydropyrimidines were investigated to clarify their predominant form in the possible from the aspects of infrared spectra. Thus, it was found that V exists as the imino-form and 2-(2-acylaminoethyl)-6-amino-4,5-dihydropyrimidines as the amino-form in the solid state. Further, it was described the synthesis of 3-acylaminopropionamidine possessing the heterocyclic ring for the purpose of potenciating the activity of benzamidopropionamidine which was studied previously.
- 公益社団法人日本薬学会の論文
- 1969-11-25
著者
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岡本 義久
School of Pharmaceutical Sciences, Kitasato University
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上田 武雄
College of Pharmaceutical Sciences, Kitasato University
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岡本 義久
School Of Pharmaceutical Sciences Kitasato University
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辻 忠和
Department of Chemistry, Japan Women's University
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岡本 義久
Pharmaceutical Institute, Keio Gijuku University
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辻 忠和
Department Of Chemistry Japan Women's University
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上田 武雄
School Of Pharmaceutical Sciences Kitasato University
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