Synthesis and Antiviral Effect of Hexahydro-s-triazines.

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概要

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• The condensation of guanidine nitrate with acetaldehyde-ammonia furnished 2-imino-4,6-dimethylhexahydro-s-triazine nitrate. 2-Imino-5-methylhexahydro-s-triazine nitrate was also prepared by the same way. The alkyl derivatives of tetrahydro-s-triazine-2 (1H)-thione and tetrahydro-s-triazin-2 (1H)-one were synthesized by the condensation of either thiourea or urea with amine and aldehyde. These compounds were screened as to their inhibitory effect on poliomyelitis virus by tissue culture method. Only 2-Imino-4,6-dimethylhexahydro-s-triazine nitrate, among the compounds screened, showed an effect, and it exerted fairly an inhibitory effect on the type-1 and -2 strains of poliomyelitis virus, but it has not so significant effect on the type-3 strain. Moreover, this compound was found to inhibit a multiplication of the Edmonstan strain of measles virus, although its effect was not so significant.

• 社団法人日本薬学会の論文
• 1962-12-25

著者

• 辻 忠和

  Pharmaceutical Institute, Keio-Gijuku University

• 上田 武雄

  Pharmaceutical Institute, Keio-Gijuku University

• 渡辺 寿美子

  Pharmaceutical Institute Keio-gijuku University

• 豊島 滋

  Pharmaceutical Institute, Keio-Gijuku University

• 豊島 滋

  慶大・医学部・薬化学研究所・化学療法部門

• 豊島 滋

  Pharmaceutical Institute Keio-gijuku University

• 辻 忠和

  Department Of Chemistry Japan Women's University

• 辻 忠和

  Pharmaceutical Institute Keio-gijuku University

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