Reaction of 1-Substituted Biguanide with Diethyl Formylsuccinate and Diethyl Succinate.
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概要
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Condensation of 1-substituted biguanide with diethyl formylsuccinate gave ethyl 2-(substituted guanidino)-4-hydroxy-5-pyrimidineacetate, which was also prepared through the reaction of 2-cyanamino-4-hydroxy-5-pyrimidineacetic acid with amine hydrochloride. The ethyl esters of 5-pyrimidineacetic acids were converted into corresponding hydrazides with hydrazine hydrate. Condensation of 1-substituted biguanide with diethyl succinate gave 4-(substituted amino)-6-amino-s-triazine-2-propionic acid, its ethyl ester and 2,2'-ethylene-bis [4-(substituted amino)-6-amino-s-triazine]. The ethyl esters of s-triazine-2-propionic acids gave corresponding hydrazides with hydrazine hydrate. The reaction of ethyl esters of s-triazine-2-propionic acids with guanidine did not afford any objective acid guanidides, but gave guanidinium salt of 4-(substituted amino)-6-amino-s-triazine-2-propionic acid.
- 公益社団法人日本薬学会の論文
- 1964-05-25
著者
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上田 武雄
Pharmaceutical Institute, Keio-Gijuku University
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高木 要
Central Research Laboratories Zeria Pharmaceutical Co. Ltd.
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高木 要
Pharmaceutical Institute, Keio-Gijuku University
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