Synthesis and Some Reactions of 6- (2-Hydroxyphenyl) -2-thiouracils
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概要
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6-(2-Hydroxyphenyl)-2-thiouracil (2a) and its 5-chloro and 5-bromo derivatives (2b, c) were synthesized by the reactions of 4-methoxycoumarin (1a) and 3-chloro- and 3-bromo-4-methoxycoumarins (1b, c), respectively, with thiourea in the presence of sodium ethoxide. In these reactions, compound 1c gave not only the pyrimidine 2c, but also the Perkin rearrangement product : N-(3-ethoxybenzofuran-2-carbonyl)thiourea (3). 2-Thiouracils 2a-c were converted to the uracil derivatives (6a, b). Reactions of 2a-c with some cyclic amines and the methylation of 2b, c with methyl iodide were also examined.
- 社団法人日本薬学会の論文
- 1983-10-25
著者
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森田 光
Central Research Laboratories Zeria Pharmaceutical Co. Ltd.
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田中 雅明
Central Research Laboratories Zeria Pharmaceutical Co. Ltd.
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高木 要
Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.
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森田 光
Itabashi Research Laboratories, Zeria Pharmaceutical Co., Ltd.
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田中 雅明
Itabashi Research Laboratories, Zeria Pharmaceutical Co., Ltd.
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高木 要
Central Research Laboratories Zeria Pharmaceutical Co. Ltd.
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