Ring Transformation of 4-Amino-1H-1,5-benzodiazepine-3-carbonitrile. The Use of Hydroxylamines as Nucleophile
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概要
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The reaction of 4-amino-1H-1,5-benzodiazepine-3-carbonitrile hydrochloride (1) with hydroxylamine gave a ring-opened compound, 3-amino-3-(o-aminoanilino)-2-cyano-2-propenaloxime (5). Compound 5 was converted to 5-(o-aminoanilino)-4-cyanoisoxazole (6) on treatment with hydrochloric acid. Compound 1 was also reacted with methoxyamine to give 2-(1'-cyano-2'-methoxyaminovinyl) benzimidazole (8). On the other hand, hydrolysis of 1 at pH 1 gave 2-cyanomethylbenzimidazole hydrochloride (12).
- 公益社団法人日本薬学会の論文
- 1980-02-25
著者
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岡本 義久
School of Pharmaceutical Sciences, Kitasato University
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上田 武雄
School of Pharmaceutical Sciences, Kitasato University
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高木 要
Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.
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岡本 義久
School Of Pharmaceutical Sciences Kitasato University
-
高木 要
Central Research Laboratories Zeria Pharmaceutical Co. Ltd.
-
高木 要
School of Pharmaceutical Sciences, Kitasato University
-
上田 武雄
School Of Pharmaceutical Sciences Kitasato University
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