Acylation of 2-Cyanomethylbenzimidazole
スポンサーリンク
概要
- 論文の詳細を見る
An acylation of 2-cyanomethylbenzimidazole (2), which has the NH and the active methylene group as active site, in acetone by the Schotten-Baumann method was carried out. The acylation occurred at the nitrogen of the imidazole ring when 2,itself, was used as a base. In these experiments, 2 was condensed with acetone to give 2-(1-cyano-2-methyl-1-propenyl) benzimidazole (4a) in the presence of trimethylamine as a base, however, 2 could not react with acetone in the presence of pyridine as a base.
- 公益社団法人日本薬学会の論文
- 1977-11-25
著者
-
岡本 義久
School of Pharmaceutical Sciences, Kitasato University
-
上田 武雄
School of Pharmaceutical Sciences, Kitasato University
-
岡本 義久
School Of Pharmaceutical Sciences Kitasato University
-
上田 武雄
School Of Pharmaceutical Sciences Kitasato University
関連論文
- Color Reaction of Cholesterol with Benzoyl Peroxide in Concentrated Trichloroacetic Acid
- Tautomeric Character of 3-Heteroarylmethylene-2-oxo-1,2,3,4-tetrahydroquinoxalines
- Studies on the Thalleioquine Reaction
- Color Reaction of Benzaldehyde with 1-Naphthol in Concentrated Sulfuric Acid
- Dimeric Steroid Formation in the Color Reaction of Cholesterol
- Color Reaction of Estrone with the Antimony Trichloride Reagent
- Color Reaction of Cholesterol in Concentrated Trichloroacetic Acid Media
- Bis (guanidinoethyl) amine Derivatives
- Ring Transformation of 4-Amino-1H-1,5-benzodiazepine-3-carbonitrile. II. Formation of Ring-opened Hydrazine Adducts
- A Direct Reductive Deamination of Amidines with Sodium Borohydride. Formation of Deaminated Compounds and Secondary Amines
- Fluorometric Determination of Hydrogen Peroxide with 4-Amino-1H-1,5-benzodiazepine-3-carbonitrile Hydrochloride
- Ring Transformation of 4-Amino-1H-1,5-benzodiazepine-3-carbonitrile. The Use of Hydroxylamines as Nucleophile
- Acylation of 2-Cyanomethylbenzimidazole
- Intramolecular Cyclization of 4-Amino-5-(2,2-dicyanovinyl)-amino-1,3-dimethyluracil
- Preparation and Hydrolysis of 4-Amino-1H-1,5-benzodiazepine-3-carbonitrile
- Reaction of Ethoxymethylenemalononitrile with 2-Aminopyridines
- The Reaction of Ethyl ω-Haloalkylimidate Hydrochloride with 2-Aminoheterocycles
- Conformational Analysis of 1,3-Diethyl-5-methyl-5-nitrohexahydropyrimidine
- Reaction of Ethyl 3-Chloropropionimidate with Aminoheterocycles
- The Reaction of Ethyl 3-Chloropropionimidate with Amino Heterocycles
- Synthesis of 2-Substituted-6-amino-4,5-dihydropyrimidine
- Syntheses of 2-Acylaminoacetamidine and 3-Acylaminopropionamidine Derivatives
- Reaction of Ethoxymethylenemalononitrile with Hydrazine Hydrate
- Reaction of ο-Aminobenzamide Derivatives with Ethoxymethylenemalononitrile and Its Analogue
- Sur la Transformation de Derives Oxadiazoliques en Oxo-4 quinazolines par Hydrogenation Catalytique
- Sur la Formation d'Oxadiazoles-1,2,4 par Action de Benzamidoximes sur des Anhydrides Isatoiques
- Sur la Formation d'un Derive Pyrazolique Original a partir d'Hydrazine et d'Ethoxymethylene Malononitrile
- ビタミンDの比色定量に及ぼすBHT-hydroperoxideの影響
- Researches on Chemotherapeutic Drugs against Viruses. XXV. Studies on the Syntheses and Antiviral Effect of 2-Dimethylaminoethyl Alkylphenyl Ethers
- Researches on Chemotherapeutic Drugs against Viruses. XXIV. Studies on the Syntheses and Antiviral Effect of 2-Alkylphenoxyalkanoic Acids
- Color Reaction of Cholesterol with the Antimony Trichloride Reagent
- Reaction of Triethyloxonium Fluoroborate with Acid Amide. III. Formation of Quinazoline and 4H-3,1-Benzoxazin-4-one Derivatives
- 1,2-Naphthoquinoneおよび1,2-Naphthoquinone Sulfonic Acidの2-Acylhydrazoneの有機試薬としての検討
- ベンゼン置換体に対するVitali-Freeman反応
- アミノアルキルベンゼンとMarquis試薬との反応
- Color Reaction of Aromatic Aldehydes with Acenaphthene in Concentrated Sulfuric Acid
- NaphthylamineとMarquis 試薬の反応
- Reaction of Triethyloxonium Fluoroborate with Acid Amide. I. Formation of Cyclic Amidine and Tetrahydropyrimidine
- D-酒石酸のアルカリ転位反応の分析的解析
- 25-II-8 ゲルろ過による脂溶性ビタミンの分離 : (X)トコフェロールのゲルろ過(研究発表 日本ビタミン学会 : 第24回大会研究)
- 1,2-Naphthoquinone-2-semicarbazone-4-sulfonic AcidとBismuthとの反応
- ゲルろ過による脂溶性ビタミンの分離(IX)ビタミンA分解物および酸化防止剤のゲルろ過における挙動
- 1,2-Naphthoquinone-2-semicarbazone類の合成および金属との反応
- Alkylated Pyrimidine Derivatives as Antiviral Agents. I. Syntheses and Antiviral Screening of Alkylpyrimidine and 5-Alkyluracil Nucleoside
- Alkylated Pyrimidine Derivatives as Antiviral Agents. III. Synthesis and Antiviral Effect of 5-Ethyluracil Nucleosides
- Alkylated Pyrimidine Derivatives as Antiviral Agents. II. Inhibition of Early Stages of Viral Multiplication by 5-Alkyluracil and 5-Alkyluracil Nucleoside
- Synthese de Pyrimidines et de Pyrazoles a partir d'Acyl-3 halogeno-5 benzofurannes
- Sur Quelques Proprietes du Phenyl-2 formyl-3 benzofuranne
- Etude de la Reactivite d'Oxo-4 tetrahydro-4,5,6,7 benzofurannes. III. Sur la Formation de Furoacridines a partir du p-Bromophenyl-2 oxo-4 tetrahydro-4,5,6,7 benzofuranne
- Etude de la Reactivite d'Oxo-4 tetrahydro-4,5,6,7 benzofurannes. II. Acces aux Furoacridines par Application de la Reaction de Friedlaender
- Etude de la Reactivite d'Oxo-4 tetrahydro-4,5,6,7 benzofurannes. I. Acces aux Furo [2,3-c]-acridines par Condensation de 1'Isatine et de 1'Acide Anthranilique
- Sur la Formation des 8-Triazines par Action de Biguanides sur l'Ethoxymethylene Acetoacetate d'Ethyle ou sur l'Ethoxymethylene Malonate d'Ethyle
- 金属塩-NaBH4/H2O系を用いる芳香族2-アミノ-N-複素環・ボラン錯体の新合成法とその利用