Researches on Chemotherapeutic Drugs against Viruses. XXV. Studies on the Syntheses and Antiviral Effect of 2-Dimethylaminoethyl Alkylphenyl Ethers
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概要
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2-Dimethylaminoethyl phenyl ether, having alkyl chain of 8〜14 carbon atoms on the benzene ring in ortho- or para-position, were synthesized by condensation of alkylphenol with 2-dimethylaminoethyl chloride. The antiviral effects of these compounds were tested against the Nakayama strain of Japanese B encephalitis virus and the Lansing strain of poliomyelitis virus. 2-Dimethylaminoethyl o-octylphenyl ether and p-octylphenyl ether had antiviral activity against the Nakayama strain in vivo. 2-Dimethylaminoethyl o-octylphenyl ether, o-decylphenyl ether, and p-octylphenyl ether had antiviral activity against the Lansing strain in vitro.
- 公益社団法人日本薬学会の論文
- 1959-10-20
著者
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上田 武雄
Pharmaceutical Institute, Keio-Gijuku University
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豊島 滋
Pharmaceutical Institute, Keio-Gijuku University
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豊島 滋
慶大・医学部・薬化学研究所・化学療法部門
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豊島 滋
Pharmaceutical Institute Keio-gijuku University
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上田 文雄
Pharmaceutical Institute Keio-gijuku University
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上田 武雄
School Of Pharmaceutical Sciences Kitasato University
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