Researches on Chemotherapeutic Drugs against Viruses. XXIX. Synthesis and Antiviral Activity of N-Alkanoyl-8-ethoxy-5-quinolinesulfonamide.

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概要

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• The seven compounds of N-alkanoyl-8-ethoxy-5-quinolinesulfonamide were synthesized and their in vitro and in vivo effects were tested on the Nakayama strain of Japanese B encephalitis virus. Among them, N-decanoyl-8-ethoxy-5-quinolinesufonamide was selected as the most effective. The optimum effective dose, effective time, acute toxicity, and minimum hemolytic action of this compound were examined and it was found to be more promising than PANS-610 in view of in vitro activity, in vivo effect, and effective time.

• 公益社団法人日本薬学会の論文
• 1960-09-25

著者

• 川畑 潤三

  Pharmaceutical Institute, Keio-Gijuku University

• 豊島 滋

  Pharmaceutical Institute, Keio-Gijuku University

• 伊藤 知男

  Pharmaceutical Institute Keio-gijuku University

• 豊島 滋

  慶大・医学部・薬化学研究所・化学療法部門

• 豊島 滋

  Pharmaceutical Institute Keio-gijuku University

• 川畑 潤三

  Pharmaceutical Institute Keio-gijuku University

• 鯉淵 弘子

  Pharmaceutical Institute, Keio-Gijuku University

• 鯉淵 弘子

  Pharmaceutical Institute Keio-gijuku University

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