Syntheses and Antiviral Effect of p-Alkylbenzenesulfonamide Derivatives

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概要

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• Seven series of compounds, i.e. p-alkylbezenesulfonamide, N-alkyl and N-(4-alkyl-phenyl) derivatives of p-toluenesulfonamide, p-alkoxybenzenesulfonamide, N-phenyl-p-alkoxybenzenesulfonamide, N-(4-alkoxyphenyl)-p-toluenesulfonamide and p-(p-alkylbenzenesulfonamido)-N-alkylbenzamide, were synthesized and examined as to their antiviral activities on viruses of Japanese encephalitis, influenza A and poliomyelitis. Several compounds were found effective for the in vitro test on Lansing strain of poliomyelitis virus. Among these effective compounds, N-phenyl-p-toluenesulfonamide was found to possess the promising in vivo activity on Lansing strain virus.

• 社団法人日本薬学会の論文
• 1964-12-25

著者

• 小林 佐知子

  College Of Pharmaceutical Sciences Kitasato University

• 辻 忠和

  Pharmaceutical Institute, Keio-Gijuku University

• 川畑 潤三

  Pharmaceutical Institute, Keio-Gijuku University

• 小林 佐知子

  Pharmaceutical Institute, Keio-Gijuku University

• 上田 武雄

  Pharmaceutical Institute, Keio-Gijuku University

• 辻 忠和

  Department Of Chemistry Japan Women's University

• 辻 忠和

  Pharmaceutical Institute Keio-gijuku University

• 川畑 潤三

  Pharmaceutical Institute Keio-gijuku University

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