Researches on Chemotherapeutic Drugs against Viruses. XXVII. Synthesis and Antiviral Activity of 1-(p-Alkylphenyl)-3-dimethylamino-1-propanol
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概要
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In order to find antiviral compounds, alkyl group was introduced into the neurotropic structure of 1-phenyl-3-dimethylamino-1-propanol and activity of the resulting alkyl derivatives were examined against the Nakayama strain of Japanese B encephalitis virus and the PR-8 strain of influenza A virus. 1-(p-Decylphenyl)-3-dimethylamino-1-propanol and 1-(p-dodecylphenyl)-3-dimethylamino-1-propanol showed in vivo effect on the Nakayama strain, and 1-(p-ethylphenyl)-3-dimethylamino-1-propanol exerted in ovo activity on the PR-8 strain.
- 公益社団法人日本薬学会の論文
- 1960-09-25
著者
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豊島 滋
Pharmaceutical Institute, Keio-Gijuku University
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豊島 滋
Pharmaceutical Institute Keio-gijuku University
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辻 忠和
Pharmaceutical Institute Keio-gijuku University
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水間 豊治
Pharmaceutical Institute, Keio-Gijuku University
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水間 豊治
Pharmaceutical Institute Keio-gijuku University
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