Syntheses and Antimicrobial Activity of 5-Alkyl-2-thiouracil Derivatives.

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概要

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• To find chemotherapeutic agents for polio, adenoviruses and toxoplasma Gondii, 2-thio-5-alkyl-6-aminouracil, 2-methylthio-5-alkyl-6-amino-4-pyrimidinol, 2-methylthio-4-chloro-5-alkyl-6-aminopyrimidine, 2-thio-5-alkyluracil and 2-thio-5-alkyl-6-methyluracil were synthesized. All of the compounds did not show any inhibitory effect on the viruses, but some of the compounds were found fairly effective against the infection of toxoplasma in mice. Death-delaying effect of 2-thio-5-hexyl-6-methyluracil, 2-methylthio-5-pentyl-6-amino-4-pyrimidinol and 2-methylthio-4-chloro-5-alkyl-6-aminopyrimidine which possess lower alkyl groups than hexyl group was found effective nearly equal to that of sulfadiazine or sulfamethazine.

• 社団法人日本薬学会の論文
• 1963-04-25

著者

• 辻 忠和

  Pharmaceutical Institute, Keio-Gijuku University

• 渡辺 寿美子

  Pharmaceutical Institute Keio-gijuku University

• 豊島 滋

  Pharmaceutical Institute, Keio-Gijuku University

• 豊島 滋

  Pharmaceutical Institute Keio-gijuku University

• 辻 忠和

  Department Of Chemistry Japan Women's University

• 辻 忠和

  Pharmaceutical Institute Keio-gijuku University

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