Studies on Pyridazine Derivatives. I. Synthesis and Antimicrobial Activity of 6-Substituted 3-Aminopyridazine and its Sulfonamido Derivatives.

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概要

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• To find more improved sulfonamide drugs, 3-sulfanilyl-6-hydroxy-, 3-sulfanilyl-6-mercapto-, 3-sulfanilyl-6-alkoxy- and 3-sulfanilyl-6-alkylthio-pyridazine and their intermediates, 3-amino-6-hydroxy-, 3-amino-6-mercapto-, 3-amino-6-alkoxy- and 3-amino-6-alkylthio-pyridazine were synthesized. Few synthetic procedures via different routes were examined as to the synthesises of 3-sulfanilyl-6-alkoxy-, 3-sulfanilyl-6-alkylthio- and 3-amino-6-methoxy-pyridazine. Activities of the compounds of 6-substituted-3-sulfanilyl-pyridazine on some kinds of bacteria and viruses were examined and among them, 3-sulfanilyl-6-methoxy-, 3-sulfanilyl-6-ethoxy and 3-sulfanilyl-6-methylthiopyridazine were found to exert remarkable antibacterial effects.

• 公益社団法人日本薬学会の論文
• 1962-07-25

著者

• 上田 武雄

  Pharmaceutical Institute, Keio-Gijuku University

• 堀江 達也

  Pharmaceutical Institute Keio-gijuku University

• 金城 清勝

  Pharmaceutical Institute Keio University

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