Syntheses and Mass Spectrometric Analysis of Amidinothiourea Derivatives

概要

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Three compounds of 1-(substituted amidino)-2-thiourea, ten compounds of 1-aryl-3-amidino-2-thiourea and fourteen compounds of 1-aliphatic and alicyclic 3-amidino-2-thiourea were synthesized to examine their antiviral effect. Further, the electron-impact induced fragmentation of 1-aryl and 1-alkyl derivatives were investigated. In the mass spectra of 1-aryl derivatives, three characteristic fragments arising from a primary fragmentation process, ArNCS^+, (M-ArNH)^+ and ArNH_2^+ were observed, and (M-SH)^+ was observed as a minor fragment. In the alkyl derivatives, (M-RNH)^+ was a main fragment, and (M-SH)^+ and CH_3 (CH_2)_n CH=NH^+_2 were minor fragments. Furthermore, the C_3H_8N_4S ion was characteristic for the higher alkyl derivatives and the RNCS ion, for the lower homologs.
公益社団法人日本薬学会の論文
1971-10-25