Studies on Antitumor Substances. V. Reaction of Thiosulfonates with Active Methylene Compounds.

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概要

• 論文の詳細を見る

• The reactions of benzyl benzene or p-toluenethiosulfonate with active methylene compounds were studied to elucidate the mechanism of anti-tumor activity of the analogous pentamethylene bismethanethiosulfonate with the expectation that any alkylation might occur. It was found that benzene or p-toluenethiosulfonate did not benzylate the active methylene compounds but one or two benzylthio groups were introduced. In the cases of less active methylene compounds, the reaction of thiosulfonates themselves occurred.

• 公益社団法人日本薬学会の論文
• 1967-08-25

著者

• 古川 潮

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 林 清五郎

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 新形 邦宏

  Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.

• 山本 順子

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 林清 五郎

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 新形 邦宏

  Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.

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