Reaction of Biguanides and Related Compounds. VIII. The Condensation of Arylbiguanides and N-Amidino-O-alkylisoureas with Diketene and Ethyl Acetoacetate

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概要

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• The reaction of arylbiguanides and N-amidino-O-alkylisoureas with diketene was found to proceed through the acylated intermediates to give pyrimidines and s-triazines. The reaction of arylbiguanides with ethyl acetoacetate was also attempted and the proportion of pyrimidines and s-triazines obtained was found to be almost equall to that in the case of the reaction with diketene. Therefore, this reaction was also elucidated to proceed via the acylated intermediates.

• 公益社団法人日本薬学会の論文
• 1973-12-25

著者

• 古川 潮

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 林 清五郎

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 吉田 孝利

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 後藤 元雄

  Faculty of Pharmaccutical Sciences, Kumamoto University

• 林清 五郎

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 吉田 孝利

  Research Institute, Daiichi Seiyaku Co., Ltd.

• 後藤 元雄

  Faculty Of Pharmaccutical Sciences Kumamoto University

• 吉田 孝利

  Research Institute Daiichi Seiyaku Co. Ltd.

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