Asymmetric Syntheses of β-Amino Acids by the Reduction of Enamines

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概要

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• Asymmetric synthesis of β-amino acids (4) was achieved by the reduction of chiral enamines (3) with 10% palladium hydroxide catalyst on charcoal or with sodium cyanoborohydride in optical purities of 3-28%. The reduction with the former catalyst afforded higher optical purities of 4 than that with the latter reducing agent. These two methods yielded opposite configurations of 4. The steric courses of the reactions are discussed.

• 公益社団法人日本薬学会の論文
• 1979-09-25

著者

• 古川 潮

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 大川原 正

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 野口 芳秀

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 寺脇 由里子

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 野口 芳秀

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 大川原 正

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 寺脇 由里子

  Faculty Of Pharmaceutical Sciences Kumamoto University

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