Reaction of Biguanides and Related Compounds. I. Reaction of Biguanides with β-Diketone

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概要

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• Biguanide derivatives were allowed to react with acetylacetone and benzoylacetone. Both of alkyl and arylbiguanides reacted with acetylacetone to give the corresponding 4,6-dimethyl-2-alkyl or arylguanidinopyrimidine. On the other hand, arylbiguanides were found to exhibit chemical behaviors different from alkylbiguanides toward benzoylacetone. Two moles of arylbiguanides reacted with benzoylacetone to give 6-arylamino-4-amino-2-phenyl-2(6'-arylamino-4'-amino-2'-methyl-1', 2', -dihydro-s-triazinyl-2'-methyl)-1,2-dihydro-s-triazine, though alkylbiguanides gave 6-methyl-4-phenyl-2-alkylguanidinopyrimidine under the similar condition. It was noted that the reaction of 1-methyl-1-phenyl-biguanide with benzoylacetone resulted in the formation of 6-methyl-4-phenyl-2-methyl-phenylguanidinopyrimidine without formation of any expected bisdihydro-s-triazine.

• 公益社団法人日本薬学会の論文
• 1971-11-25

著者

• 古川 潮

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 林 清五郎

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 藤野 洋子

  Institute for Medical and Dental Engineering, Tokyo Medical and Dental University

• 藤野 洋子

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 藤野 洋子

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• 林清 五郎

  Faculty Of Pharmaceutical Sciences Kumamoto University

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