Reaction of Biguanides and Related Compounds. IX. Condensation of N-Amidino-O-alkylisourea and 1-Substituted 3-Amidino-2-thiourea with Benzil

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概要

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• The reactions of N-amidino-O-alkylisourea and 1-substituted 3-amidino-2-thiourea with benzil were examined. The reaction of N-amidino-O-alkylisourea with an equivalent amount of benzil in ethanol gave 5,5-diphenylglycocyamidine by heating for 10 hr under reflux, 5,5-diphenylglycocyamidine and 2-alkoxyamidinylidene-5,5-diphenylhydantoin by heating for 2 hr under the similar conditions and 2-alkoxyamidinylidene-5,5-diphenylhydantoin and 3a, 6a-diphenylglycoluril-2,5-dialkoximidoylimide by treatment for 1 hr at room temperature. Similarly, heating of 1-aryl-3-amidino-2-thiourea with benzil in ethanol for 10 hr under reflux gave 5,5-diphenylglycocyamidine. On the other hand, by heating in ethanol in the presence of potassium hydroxide for 2 hr under reflux, 2-arylthiocarbamoyl-5,5-diphenylglycocyamidine.

• 公益社団法人日本薬学会の論文
• 1974-01-25

著者

• 古川 潮

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 林 清五郎

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 小島 洋子

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 吉田 孝利

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 松岡 和忠

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 林清 五郎

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 吉田 孝利

  Research Institute, Daiichi Seiyaku Co., Ltd.

• 松岡 和忠

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 吉田 孝利

  Research Institute Daiichi Seiyaku Co. Ltd.

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