Preparation of Optically Active γ-Hydroxyethyl α, β-Unsaturated γ-Lactone Using an Enzymatic
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概要
- 論文の詳細を見る
γ-Hydroxyethyl α, β-unsaturated γ-lactone (2) is a promising intermediate for the synthesis of eldanolide and cis, cis-1,2,3-trisubstituted cyclopentane, which could be converted to 11-deoxyprostaglandins. In order to prepare optically active 2,enzymatic hydrolysis of (±)-trans-cyclohexene-4,5-diacetate with Pseudomonas fluorescens lipase was examined, and the monoalcohol ((-)-6,>99%ee)with R-configuration was obtained in accored with prediction based on the three-site model proposed by us. Compound (-)-6 could be converted to the chiral lactone ((-)-2) via a sequence of reactions involving ring cleavage.
- 社団法人日本薬学会の論文
- 1989-05-25
著者
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末宗 洋
Faculty of Pharmaceutical Sciences, Kyushu University
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酒井 浄
Faculty of Pharmaceutical Sciences, Kyushu University
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酒井 浄
Faculty Of Pharmaceutical Sciences Kyushu University
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肥塚 美千代
Faculty of Pharmaceutical Sciences, Kyushu University
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鎌下 知子
Faculty of Pharmaceutical Sciences, Kyushu University
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末宗 洋
九州大学薬学部
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末宗 洋
九州大学大学院薬学府
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鎌下 知子
Faculty Of Pharmaceutical Sciences Kyushu University
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肥塚 美千代
Faculty Of Pharmaceutical Sciences Kyushu University
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末宗 洋
九州大学大学院薬学研究院
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