ロジウム錯体触媒によるヒドロアシル化反応 : 分子内反応から分子間反応への展開

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概要

• 論文の詳細を見る

• Rh-catalyzed hydroacylation reaction can be classified into intramolecular reaction (cyclization) and intermolecular reaction. The intramolecular hydroacylation of 4-pentenals by Rh-complex was clarified about 40 years ago. Intramolecular hydroacylation by Rh-complex has been developed into catalytic reaction, enantioselective reaction, and medium-ring formation reaction. At the beginning, however, Rh-catalyzed intermolecular hydroacylation reaction did not proceed because of decarbonylation side reaction, but, the chelation of aldehyde having an additional functional group suppressed the decarbonylation, and the Rh-catalyzed intermolecular hydroacylation reaction using the chelation of aldehyde proceeded. Especially, the double chelation of both salicylaldehyde and diene promoted the intermolecular hydroacylation under mild reaction conditions. The Rh-catalyzed intermolecular hydroacylation has been developed into diastereoselective and enantioselective reactions.

• 社団法人 有機合成化学協会の論文
• 2011-03-01

著者

• 末宗 洋

  九州大学大学院薬学研究科

• 末宗 洋

  九州大学薬学部

• 末宗 洋

  九州大学大学院薬学府

• 今井 幹典

  北海道薬科大学

• 田中 正一

  長崎大学大学院医歯薬学総合研究科

• 末宗 洋

  九州大学大学院薬学研究院

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