Conversion of (-)-Limonen-10-ol to 11-Deoxyprostaglandin
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概要
- 論文の詳細を見る
This paper describes a conversion of (-)-limonen-10-ol to the key intermediate (1) for 11-deoxyprostaglandin. The 3,4-cis-disubstituted cyclopentanone (2), which was easily obtained from (-)-limonen-10-ol in a stereocontrolled fashion by means of Rh(I)-catalyzed cyclization via the 4-pentenal derivative, could be directly converted to the bicyclo[3.3.0]octenone (3) by treatment with KHSO_4 in boiling benzene. Compound 3 with a double bond at the favorable position was converted to 1 by way of fission of the double bond and subsequent modification of substituents on the five-membered ring.
- 公益社団法人日本薬学会の論文
- 1986-11-25
著者
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末宗 洋
Faculty of Pharmaceutical Sciences, Kyushu University
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酒井 浄
Faculty of Pharmaceutical Sciences, Kyushu University
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酒井 浄
Faculty Of Pharmaceutical Sciences Kyushu University
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佐伯 清太郎
Faculty of Pharmaceutical Sciences, Kyushu University
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末宗 洋
九州大学薬学部
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末宗 洋
九州大学大学院薬学府
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佐伯 清太郎
Faculty Of Pharmaceutical Sciences Kyushu University
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丸岡 博
Faculty of Pharmaceutical Sciences, Kyushu University
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丸岡 博
Faculty Of Pharmaceutical Sciences Kyushu University
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末宗 洋
九州大学大学院薬学研究院
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