Studies on Tertiary Amine Oxides. LXXVII. The Pseudo-Gomberg Reaction of 4-and 2-Aminopyridine 1-Oxides
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概要
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The 1-oxido-4-pyridyl radical generated by the reaction of 4-aminopyridine 1-oxide with amyl nitrite reacted smoothly with aromatic hydrocarbons, including five-membered heterocycles, i.e. thiophene, furan and pyrrole, to give the arylated products when acetic acid was used as the solvent. The relative rates of reaction with the 1-oxido-4-pyridyl radical indicated that this radical is electrophilic, and this finding was supported by a comparison of molecular orbital energy levels. 2-Aminopyridine 1-oxide also undergoes a similar reaction.
- 公益社団法人日本薬学会の論文
- 1984-05-25
著者
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佐伯 清太郎
Faculty of Pharmaceutical Sciences, Kyushu University
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近藤 幸子
Faculty Of Pharmaceutical Sciences Kyushu University
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浜名 政和
Faculty of Pharmaceutical Sciences, Kyushu University
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林 貴昭
Faculty of Pharmaceutical Sciences, Kyushu University
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林 貴昭
Faculty Of Pharmaceutical Sciences Teikyo University
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佐伯 清太郎
Faculty Of Pharmaceutical Sciences Kyushu University
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浜名 政和
Faculty Of Pharmaceutical Sciences Kyushu University
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