Studies on Tertiary Amine Oxides. XLIV. Reactions of Aromatic N-Oxides with N-Acylmethylpyridinium Salts in the Presence of Acylating Agents
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概要
- 論文の詳細を見る
N-Acylmethylpyridinium salts (Ia-c) were applied to some pyridine and quinoline N-oxides in the presence of acetic anhydride. 4-Methoxyquinoline 1-oxide (IV) readily reacted with Ia-c to give N-(α-acyl-4-methoxy-2-quinolylmethyl) pyridinium compounds (Va-c) in good yields. Whereas N-oxides of lepidine (VIII), pyridine (XII) and 4-picoline (XV) reacted similarly with N-acetonylpyridinium chloride (Ia). Quinaldine and 2-picoline N-oxides did not react even with Ia. The pyridinium salts thus obtained afforded smoothly the corresponding quinaldyl (XVIIIa, b ; XIX) or α-picolyl ketones (XXI, XXII) upon treatment zinc powder and acetic acid. The tautomeric structures of the quinaldyl ketones (XVIIIa, b ; XIX) were discussed.
- 公益社団法人日本薬学会の論文
- 1973-04-25
著者
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山崎 企善
Faculty of Pharmaceutical Sciences, Fukuoka University
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浜名 政和
Faculty of Pharmaceutical Sciences, Kyushu University
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本庄 紀子
Faculty of Pharmaceutical Sciences, Fukuoka University
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野田 寛治
Research Laboratories Hisamitsu Pharmaceutical Co. Inc.
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浜名 政和
Faculty Of Pharmaceutical Sciences Kyushu University
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山崎 企善
Faculty Of Pharmaceutical Sciences Fukuoka University
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野田 寛治
Faculty of Pharmaceutical Sciences, Fukuoka University
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本庄 紀子
Faculty Of Pharmaceutical Sciences Fukuoka University
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