Studies on Tertiary Amine Oxides. XVI. Reactions of Quinoline 1-Oxides with Compounds Containing Reactive Hydrogens in the Presence of Acetic Anhydride.
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概要
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Quinoline 1-oxides were found to react smoothly with compounds containing reactive hydrogens in the presence of acetic anhydride, producing the corresponding 2-substituted quinolines. The yields were generally good to excellent in the reactions of ethyl cyanoacetate, 1,3-indandione, diethyl malonate, diethyl nitromalonate, ethyl nitroacetate (e. g. ethyl α-cyano-2-quinolineacetate in 88% yield), but acetone, acetophenone or phenylacetonitrile could not enter into the reaction. The reaction of quinoline 1-oxide using benzoyl chloride instead of acetic anhydride and those of pyridine 1-oxides in the presence of acetic anhydride proceeded similarly but in much lower yields.
- 公益社団法人日本薬学会の論文
- 1963-04-25
著者
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浜名 政和
Institute of Pharmaceutical Sciences, Faculty of Medicine, Kyushu University
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山崎 企善
Faculty Of Pharmaceutical Sciences Fukuoka University
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山崎 企善
Institute of Pharmaceutical Sciences, Faculty of Medicine, Kyushu University
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